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Second, excess intracellular iron is sequestered by cytosolic ferritin, and can be dynamically released upon iron depletion via ferritinophagy 139,140

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Additional caution or exclusion may be necessary for patients with: Pregnancy or breastfeeding Active cancer or a history of certain cancers Uncontrolled diabetes Significant heart, liver, or kidney disease Pituitary or endocrine disorders Severe sleep apnea Active infection A history of serious allergic reactions Medication interactions A condition requiring urgent conventional treatment A diagnosis that excludes one peptide does not necessarily exclude every peptide, which is why product-specific evaluation is necessary